Effect of Prostaglandin E1 on entrapment neuropathy of diabetic rats
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چکیده
INTRODUCTION: The diabetes mellitus (DM) is often associated with entrapment neuropathy, such as carpal tunnel syndrome (CTS). In CTS, repetitive trauma and ischemia are thought to be important in its pathogenesis [1]. We hypothesized that optimization of blood flow may be beneficial for entrapment neuropathies associated with DM. It is well known that DM rats housed in a grid cage develop a hindfoot tibial mononeuropathy (tarsal tunnel syndrome) [2]. We speculate that TTS rat model has two independent factors, i.e. repetitive trauma and impaired circulation, that increase the vulnerability of nerve. Prostaglandin E1 (PGE1) has various vasotropic effect. The purpose of the present study was to investigate the effect of PGE1on entrapment neuropathy of the diabetic rats.
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